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I don't represent anyone but myself (I'm always skeptical about these posts). I know everyone is different. I've been depressed to one degree or another my whole life, and have tried nearly every medicine that's come along, from the early tri-cyclics through MAO inhibitors, to SSRI/SNRIs. None worked well enough in the long run to compensate for the side effects (sexual dysfunction, weight gain, others). After 3 years of mild depression and no medicines, things got severe again. I'm in week 3 of Pristiq. Mood improved within 24 hours, and I feel as though my brain's turned on again. I have mild side effects (sleep and jaw clenching), but these are tolerable for the mood improvement. Hope it keeps working, and wish everyone good luck.

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