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The vagal neuromodulators are preferably in an amount sufficient to reduce a side-effect of the CNS active agent.

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The release of the (NM) contained in delayed-release (second) dosage form compartment initiated (meaning of "form compartment initiated" not clear) at least one hour after the first CNS active agent contained dosage form initiates release, with the initiation of the release generally occurring no more than six hours after initiation of release of CNS active agent from the first dosage form.

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Further, as is disclosed herein, this method can create a synergistic effect among the various ions present.

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