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The physician has recommended 2 weeks of combination therapy with omeprazole and another drug for a patient diagnosed with a peptic ulcer caused by Helicobacter pylori.

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Five widely used PPIs (omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole) and the recently approved dexlansoprazole, are orally available ().

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It is also indicated for maintenance therapy of erosive esophagitis; however, studies do not extend beyond six months of use.

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Results of numerous clinical trials indicate that oral pantoprazole is safe and well tolerated for short-term treatment of GERD and for longer term maintenance therapy in patients with healed erosive esophagitis.

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Miller Stage II or III) with at least 1 of 3 symptoms typical for reflux esophagitis (acid eructation, heartburn, or pain on swallowing) were randomized to receive either 40 mg intravenous pantoprazole or 40 mg oral pantoprazole daily for 5 days.

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