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Five widely used PPIs (omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole) and the recently approved dexlansoprazole, are orally available ().

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Tablets should not be crushed or chewed as this will allow the medication to enter into the patient's body too quickly.

It is also indicated for maintenance therapy of erosive esophagitis; however, studies do not extend beyond six months of use.

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Results of numerous clinical trials indicate that oral pantoprazole is safe and well tolerated for short-term treatment of GERD and for longer term maintenance therapy in patients with healed erosive esophagitis.

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Miller Stage II or III) with at least 1 of 3 symptoms typical for reflux esophagitis (acid eructation, heartburn, or pain on swallowing) were randomized to receive either 40 mg intravenous pantoprazole or 40 mg oral pantoprazole daily for 5 days.

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