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Clinicians should very carefully weigh the risks and benefits of initiating ESAs in this range of anemia as outlined elsewhere in this guideline update (section IIIA and ), and promptly discontinue ESAs in patients who do not achieve the desired benefit in the appropriate timeframe.

Therapy with Erythropoiesis-Stimulating Agents and Renal and Nonrenal Outcomes.

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When adjusting therapy consider hemoglobin rate of rise, rate of decline, ESA responsiveness and hemoglobin variability.

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Although maintenance doses of up to 525 Units per kg of body weight three times a week have been administered, the maximum maintenance dose recommended by the manufacturer is 300 Units per kg of body weight three times a week.

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Future randomized studies are warranted to examine whether vitamin D directly affects erythropoiesis.

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This article explores topics such as side effects, dosing, and safety precautions.

PROCRIT can be injected into your body using two different ways (routes) as described below.

Evaluation and Determinants of Underprescription of Erythropoiesis Stimulating Agents in Pre-Dialysis Patients with Anaemia.

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Compare the efficacy of recombinant epoetin alfa or epoetin beta with vs without parenteral iron in anemic, iron-replete patients with nonmyeloid malignancies.

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Administration of antiretroviral agents to HIV-positive mothers before birth and during labor and delivery, and to newborns for the first 6 weeks of life, markedly decrease the risk of vertical transmission of HIV infection.

Health-related quality of life of pediatric patients receiving allogeneic stem cell or bone marrow transplantation: Results of a longitudinal, multi-center study.

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Cost-Utility Analysis of Erythropoietin for Anemia Treatment in Thai End-Stage Renal Disease Patients with Hemodialysis.

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Anemia associated with chronic kidney disease (CKD): Individualize dosing and use the lowest dose necessary to reduce the need for RBC transfusions.

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These drugs should not be used if you are not receiving chemotherapy or if you are receiving chemotherapy to cure the cancer rather than as a palliative treatment.

The guideline panel strongly supports additional research to more clearly define risks of ESA use in anemic cancer patients receiving chemotherapy, and factors that determine those risks.

Progression-free survival at 3 years was lower in the epoetin alfa-treated group compared to control (59% vs.

The Use of Observational Health-Care Data to Identify and Report on Off-Label Use of Biopharmaceutical Products.

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This decision is made on an individual project basis according to the nature of the trial, the questionnaires and translations to be used, the sponsor, and existing contractual arrangements.

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The Functional Assessment of Cancer Therapy-Fatigue.

Use of Erythropoiesis-Stimulating Agents in Patients With Anemia of Chronic Kidney Disease: Overcoming the Pharmacological and Pharmacoeconomic Limitations of Existing Therapies.

Baseline and periodic monitoring of iron, total iron-binding capacity, transferrin saturation, or ferritin levels and instituting iron repletion when indicated, may be valuable in limiting the need for epoetin or darbepoetin, maximizing symptomatic improvement for patients, and determining the reason for failure to respond adequately to ESA therapy.

Finally, a growing body of research has illustrated clinically significant differences and changes in scores in FACIT scales, aiding in study sample size determination and interpretation of study results.

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This medication is red and your urine may appear orange or reddish in color for 1-2 days after the infusion.

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The shape of the surface plot in Figure shows that increases in TSAT over the range from 0% to 35% result in a steeper increase in Hb response than changes in ferritin over the entire range of physiologically plausible values.

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If approved, we believe our biosimilar rituximab will help broaden access to this important therapy and liberate healthcare resources that can be used to fund other innovative medicines.

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Other specific treatments, such as iron, folate, or vitamin B6 or B12 supplements, can reverse anemia caused by nutritional deficiencies.

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