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More than 80% of D 2 receptors were found to be occupied in patients with EPS who were taking neuroleptics, in agreement with results showing that clinical symptoms of PD began when over 80% of nigral neurons had degenerated.
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Entacapone and tolcapone, two inhibitors of another enzyme system called catechol-o-methyl transferase (COMT), may soon reach the market as early studies suggest that they effectively treat PD symptoms with fewer motor fluctuations and decreased daily L-dopa requirements.
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The main difference between PD and Essential Tremor, however, is that the Essential Tremor happens during an action and not at rest.
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Amantadine is a glutamate (NMDA) blocking drug that can control symptoms in early states of Parkinson's disease to lessen involuntary movements caused by levodopa.
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